T The Picarro PI2124 gas concentration analyzer
ensures ultra-low residual hydrogen peroxide levels
to help avoid oxidation and safeguard drug stability in
isolated GMP pharmaceutical manufacturing applications.
Production environment decontamination with vaporized
hydrogen peroxide (VHP) is the industry standard. While
VHP technology offers many performance and safety
benefits, residual H2O2 can easily oxidize pharmaceutical
products. Biologic products are especially vulnerable, often
showing significant oxidation even when exposed to low
concentrations of H2O2 (ppb range).
The Picarro PI2124 analyzer can continuously measure
H2O2 levels down to 3 ppb with precision better than
1 ppb. The analyzer is optimized for GMP applications.
Installation and operation qualification is quick and easy,

as is validation with commercially available surrogate gases. The built-in software of the PI2124, designed to assist with 21 CFR part 11 compliance, offers strict regulations on electronic records, time stamps and audit trails. Combined with detailed validation reports, software and system documentation, the PI2124 offers comprehensive and tightly controlled data management software that complies with pharmaceutical and commercial manufacturing regulations. Operating the PI2124 analyzer is simple and costeffective—it requires no wet chemistry or consumables. Patented Picarro cavity ring-down spectroscopy (CRDS) technology has no moving parts and incorporates wavelength monitoring, providing long-term stability and reliability, as well as infrequent calibration and maintenance.